Hi,
I am trying to recreate the DepMap dependency tag using your RNAi and CRISPR data which is described as: ‘a cell line is considered dependent if it has a probability of dependency greater than 0.5’
However, when using this simple function as described [1], the number of cell lines labelled as dependent is similar but not equal to what is displayed online.
Is there further filtering done to the dependence cell line value?
Thankyou,
Jude
[1] (is_dependent ← function(score, threshold = -0.5) {
if (is.na(score)) {
return(FALSE)
} else {
return(score < threshold)
}
})