CRISPR (DepMap Public 23Q2+Score, Chronos) - download

[arunprasath]

Hi,
When searching for a gene, we can view the corresponding CRISPR score (DepMap Public 23Q2+Score, Chronos): 1094/1095. Is there a downloadable file for all genes containing this value (e.g. 1094/1095)?
Thanks,
Arun

[vidat]

I think your question is covered in the answers to this post Getting dependent cell line list of strongly selective genes from DepMap (CRISPR + Achilles) - #5 by pmontgom

@pmontgom

you can download CRISPR_gene_dependency.csv from the 22Q1 release (because the tile says the dataset is “CRISPR (DepMap 22Q1 Public + Score)” )

Now, if you pull out data for the gene you’re interested in then you can filter the lines for those who has a “probability of dependency” value which is > 0.5 (ie: The line has a gene effect value which looks more like one from an essential gene then a non-essential gene in that line) Those are the 778 lines the tile is talking about.