I’m interested in figuring out how I can download a list of the genes that are scored as “common essential” by the most recent CRISPR (DepMap Public 23Q2+Score, Chronos) data as defined in the portal. Can anyone help direct me on how to develop that curated list of genes? Thanks.
You can download the table of data the portal uses from https://depmap.org/portal/api/download/gene_dep_summary and filter for those rows which have Dataset == “DependencyEnum.Chronos_Combined”
In that table, there’s a column named “Common Essential” which marks which genes passed the cut off we use for declaring a gene as “common essential”.