Common essential gene list

Q&A
1

Hello,

I’m interested in figuring out how I can download a list of the genes that are scored as “common essential” by the most recent CRISPR (DepMap Public 23Q2+Score, Chronos) data as defined in the portal. Can anyone help direct me on how to develop that curated list of genes? Thanks.

2

You can download the table of data the portal uses from https://depmap.org/portal/api/download/gene_dep_summary and filter for those rows which have Dataset == “DependencyEnum.Chronos_Combined”

In that table, there’s a column named “Common Essential” which marks which genes passed the cut off we use for declaring a gene as “common essential”.

Thanks,
Phil

3

Hi Phil,
What does it mean when a gene indicated as FALSE or TRUE in the strongly selective column? Thanks.