Why do some cell lines have multiple SequencingID profiles in OmicsExpressionTPMLogp1HumanProteinCodingGenes.csv?
I see that one profile is marked as “IsDefaultEntryForModel”, but I don’t understand what gives rise to the different sequencing profiles. Is it different sequencing processing pipelines? If so, what are the different pipelines used?
There can be multiple reasons why a model can have more than one Sequencing IDs (different growth conditions within one model, repeated sequencing, etc.). Each SequencingID represents a unique sequencing and those within the same model can be considered replicates to some extent. The expression processing pipeline is identical across all samples in each release.
I’d recommend checking out the more detailed walkthrough in the overview tab of our download page.