Hi, I am running genome wide crispr on CNS cell lines and need to define common essential genes as a positive gRNA depletion control. How do I get the list of common essential genes?
Also are common essential are define as genes that is essential across all cell lines, does not matter which tissue there are from, or narrowing it down to specific tissue is important because genes behave differently across different tissues?
In shinnyDepMap website https://labsyspharm.shinyapps.io/depmap/
I am able to see the score of gene essentiality, however, is there a way to bunch up a bunch of gene sets that have high dependency score?