PRISM Drug AUC larger than 1 meaning?

Q&A
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I found that PRISM drugs with screen_id “HTS002” could have auc larger than 1. What does larger than 1 mean? Does it mean the cells proliferate more with the drug treatment rather than being inhibited?

Thx!

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Hi! Typically an AUC larger than 1 is due to noise in the data as we see higher variability in doses that do not inhibit, however, theoretically it does mean that the cells proliferated more with drug treatment. We now cap AUC values at 1 for most PRISM data

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Thanks for your reply!
Then, would it be appropriate for me to covert all >1 auc values to 1 (without changing those <1) ?

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Yes exactly. However, I would only change them if you needed to make them consistent with another dataset where the AUC was capped

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