I’ve been working with lymphoid and myeloid cell lines recently and noticed that the majority of CML cell lines are referenced by their OncotreeCode of CML, whilst a few others are referenced by CMLBCRABL1. I had a look on Cellosaurus for these CML cell lines and found the vast majority of these cell lines also contain the BCR-ABL fusion. I’m a bit confused why these cell lines have been classified separately to the other CMLBCRABL1 cell lines, and if there is a reason why I should indeed be keeping these separated for downstream analyses?
If not, is this a bug in how the OncotreeCodes have been mapped to respective cell lines? Is their documentation anywhere on how you map the OncotreeCodes to cell lines?
e.g. JK-1 (ACH-000241) is classified as CML by OncotreeCode but also contains BCR-ABL1 fusion according to Cellosaurus (https://www.cellosaurus.org/CVCL_2079 & see ref Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in chronic myeloid leukaemia: a FISH mapping study of CML patients and cell lines - PMC).