Hello,
I’m currently trying to use methylation file from the “Methylation (1kb upstream TSS)” custom downloads page (downloaded file = Methylation_(1kb_upstream_TSS)_subsetted_NAsdropped.csv) to investigate methylation at some genes of interest. However, some promoter/cell line values are missing (blank values, not NaN). These blank values are not consistent between cell lines, however, some gene promoters seem to have a higher representation of blank values than others.
I can’t find any documentation of what these blank values represent. Could you please explain what I should interpret when a cell line / promoter value is missing? Are the gene promoters with a higher representation of missing values still reliable in the data that is there?
Thanks for your help!