Missing Values in the Promoter Methylation File

Hello,

I’m currently trying to use methylation file from the “Methylation (1kb upstream TSS)” custom downloads page (downloaded file = Methylation_(1kb_upstream_TSS)_subsetted_NAsdropped.csv) to investigate methylation at some genes of interest. However, some promoter/cell line values are missing (blank values, not NaN). These blank values are not consistent between cell lines, however, some gene promoters seem to have a higher representation of blank values than others.

I can’t find any documentation of what these blank values represent. Could you please explain what I should interpret when a cell line / promoter value is missing? Are the gene promoters with a higher representation of missing values still reliable in the data that is there?

Thanks for your help!

Hello! Just following up. Still hoping to get some clarity on the representation of missing data in this dataset.

Thank you!