Missing orange (damaging) and red (hot-spot) dots on perturbation plots

Issues and Bugs
1

Hi Guys,

Thank you for developing and maintaining this amazing resource! I have a question, which might as well being a bug: I have noticed that on perturbation view on the gene pages, I can’t see cell lines with damaging (orange) or hot-spot (red) mutations recently (not ever for KRAS). It might be that these cell lines are just covered by blue dots, or something else has changed, because I firmly remember there were quite many of them, especially for essential genes. However browsing many genes, I could not see any. I can imagine something has changed because the 23Q2 release was very recently.

Unfortunately I cannot manually check this because there are just too many dots, however it would take no time for you.

Thanks for looking into this for me.
Best,
Daniel

2

Hello,

Thanks for bringing this to our attention, and it looks like I must have not noticed your message when you first posted it. Someone forwarded it to me today, and you’re absolutely correct: The coloring by mutational status is broken and it broke due to a small change that was introduced in the 23Q2 release.

I’ve made fix for this which I’m planning on deploying on Monday morning.

Thanks again for reporting this!

Phil

3

Hello,

The fix for this has been deployed and I’ve confirmed the colors are showing up correctly again.

Thanks,
Phil

4

Hi @pmontgom ,

Thank you so much for picking up the issue, I was not sure if the reason behind the lack of colors was simply software related or there were some underlying issues with the data, which I would expect to be much harder to resolve. Great to hear that the fix is out.

Best,
Daniel