Is there a threshold in Drug Sensitivity AUC?

Is there a threshold in Drug Sensitivity AUC, below which it is considered that the drug has an impact on cell line proliferation? which threshold?
Similarly, does a threshold also exist in the PRISM Repurposing Primary Screen dataset?


For the Primary screen, the values are log2(Viabilities) at 2.5uM, and historically, we considered 30% viability (corresponding to log2(0.3) =~ -1.74 as a “sensitivity threshold.”

For AUC, it is trickier since it is also a function of the dose range screened for the drug. I don’t know the particular analysis you are following, but my recommendation would be scaling AUCs (maybe z-scores) and treating cell lines on the left tail (maybe z < -2) as sensitive lines.