Essentiality score calculation

Q&A
1

How can we calculate the essentiality score for a given cell line?

2

I’m afraid I don’t know what a cell line essentiality score is.

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3

Hi there,

Are you referring to the gene essentiality scores derived from the CRISPR screening data?

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4

Yes, we are trying to find out the gene essentiality score derived from CRISPR screening data.

5

We’re using the CERES model. Please see this paper, and this preprint, for more details on the methodology.