What is CERES score？

Q&A
1

Hey guys, I recently read a research paper that mentioned something called a “CERES score.” It seems to be related to cell lines, but I’m having trouble understanding its exact definition.

2

Hi, I can’t give you the exact definition, but at a high level the CERES scores is calculated for each cell line-gene combination, and it tells you for cell line X how much it depends on gene Y. It’s sometimes also called a dependency score for that reason. A rough rule of thumb on interpreting the CERES scores: a 0 means there is no dependency; a -1 is the score observed for known pan essential genes.

A newer version of the dependency score is CHRONOS which I believe uses CERES as input.

Hope this helps.

3

I’ll also offer that we now refer to this as “Gene Effect” on the portal. CERES was the original method that computed Gene Effects with this scale as @dllahr described, but we now we use Chronos, our newer method, to compute a score with the same scale.

Thanks,
Phil