Breast cancer cell line/BRCA1 status

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1

The Breast cancer cell line HCC1937 is listed as a BRCA1 WT, or this cell line is a BRCA1 mutant https://portals.broadinstitute.org/ccle/page?cell_line=HCC1937_BREAST
Can you explain the discrepancy between databases? and possibly rectify the BRCA1 mutation status of this cell line?
thanks,
Mirella

2

Hi

I’ve questioned DepMap about this before and this occurs because it is considered a putative germline mutation and filtered out in DepMap. The CCLE database has moved to DepMap and so you might be seeing older version of this data prior to that mutation being filtered.

Cheers