Are these two cell lines same?

[bzhang]

I think these two cell lines in CCLE_gene_cn.csv from 22Q2 release are same(see below). Would you please check it and let me know. Thanks.

ACH-000232	U-251 MG	U251MG	U251MG_CENTRAL_NERVOUS_SYSTEM	U251-MG	905983	Male	HSRRB	CVCL_0021	1913	central_nervous_system	Primary	Brain Cancer	Astrocytoma	75	SIDM00111		central_nervous_system	glioma	astrocytoma					PT-88IC1n		Astrocytoma	C60781
ACH-001172	U-251 MG	U251MGDM	U251MGDM_Brain			Male	HSRRB			central_nervous_system	Primary	Brain Cancer	Astrocytoma	75			central_nervous_system	glioma	astrocytoma					PT-88IC1n

[pmontgom]

Hello,

The relationship between these two lines is explained in the following post:

[IMPORTANT UPDATE] Fingerprinting data corrections (21Q3 release)

As part of an ongoing effort to update and improve our data analysis pipelines and release processes, we performed a systematic SNP fingerprinting analysis of all the sequencing data used in DepMap, using the Crosscheck tool (Javed et al., 2020). This allowed us to test whether our sequencing data for a given cell line were internally consistent, and whether cell lines identified as genetically matched agreed with annotations for derivative/isogenic models. Wherever possible, we also compared ou…

In short, ACH-001172 and ACH-000232 both look like they are U251MG, however, ACH-001172 shows a distinct CN profile suggesting that it has drifted significantly from U251MG. That led us to decide to keep it registered as a distinct cell line separate from ACH-000232.

Thanks,
Phil