Dear DepMap members, I am interested in checking the drug sensitivity of melanoma lines to atorvastatin drug in relation to the LDLR protein levels. I created a graph but not sure what X and Y mean exactly. I am attaching a screen shot of the graph.
Specific questions are
- Do positive values on Y axis indicate the drug is more toxic to cancer cells? What is the definition of Drug sensitivity and what assay was used to determine it?
- On X axis, what is the meaning of numbers from -2 to +1? Is this expression level arbitrary when cells were treated with this compound and vehicle control followed by mass spec? -2 means 2 fold reduction in the expression levels of LDLR?