Drug sensitivity replicate-level dose

Q&A
1

Hello,

I am confused with the y-axis which represented drug sensitivity replicate-level dose. Does higher value mean higher drug sensitivity? Thank you for the answers.

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2

Hi Fei,

No, the y-axis corresponds to fold-change value relative to the DMSO control, i.e. lower the value means more sensitive to the drug perturbation. But also, I would suggest using replicate collapsed data as opposed to individual replicates (e.g. using AUC values for CTD2 dataset).

Warmly,
Mustafa