Can CERES score be comparable across cell lines?

Hi, I have a question about the CERES score. For example, if EGFR CERES score is lower in cell line A than B. Can I say that EGFR has more important role in A than B? Furthermore, if I do a correlation between expression and CERES score across all cell lines in one gene, and saw a strong negative correlation. Can I say that there’s a strong correlation in this gene between its expression and dependency? Or I cannot interpret it like that?

Thanks for any replies!

Hi Shaowen, yes, those are both correct interpretations.