Values in OmicsCNGene.csv 24Q2 release

Dear DepMap team,

Would you please explain why the values in the 24Q2 Omics Gene.csv file are changed (lower) compared to the previous versions such as 23Q2 and 23Q4? I know PureCN was used to generate the absolute copy number data in the current release. However, I don’t understand why the CN values on the gene level are much lower than the previous releases.

Best regards,

Hi Alice,

Starting from 24Q2, our relative copy number matrix is no longer log2-transformed to be consistent with our absolute copy number data. Please refer to our release announcement for details on other changes we made that might be relevant.