Values in OmicsCNGene.csv 24Q2 release

Issues and Bugs
1

Dear DepMap team,

Would you please explain why the values in the 24Q2 Omics Gene.csv file are changed (lower) compared to the previous versions such as 23Q2 and 23Q4? I know PureCN was used to generate the absolute copy number data in the current release. However, I don’t understand why the CN values on the gene level are much lower than the previous releases.

Best regards,
Alice

2

Hi Alice,

Starting from 24Q2, our relative copy number matrix is no longer log2-transformed to be consistent with our absolute copy number data. Please refer to our release announcement for details on other changes we made that might be relevant.

Thanks,
Simone