PANC1005 (ACH-000060) KRAS Mutation Status


The PANC1005 line is well characterized as having a KRAS G12D mutation, but this is missing from the latest release of DepMap data while present in the older releases. Is this is indeed the case or have I made a mistake in querying the data?

Thank you.


Thanks for pointing this out. We updated our mutation calling pipeline to use Mutect2 starting from 22Q4. While it shows an improvement compared to the old pipeline, it appears that we are dropping well characterized mutations such as this one because they have been classified as germline.

We are currently investigating this and working on improving our whitelisting process. Thanks!