First of all, thanks to everyone who has contributed to making this great resource! I’m pretty new to working with all of this data, so sorry if my question is a bit naive.
I was wondering if the Novartis/Drive data contained in RNAi combined file D2_combined_gene_dep_scores.csv was the most recent version released by the Drive team, or if it was from a certain snapshot in time.
Also, I noticed different cell lines come up when ranking dependencies on a certain gene when I use the Novartis/Drive interface (DRIVE DATA PORTAL) vs the D2_combined data from the file above. I assume this is due to different ways of processing the data and accounting for off-target shRNA effects (Ataris vs Demeter2). Is this a correct assumption, or is there something else I should consider as well?