Yep, this is confusing when you first use the CTRP data. The data are the actual AUCs, but it scaled weirdly. In the original CTRP publication from 2013, they decided to scale the AUCs by multiplying the AUC by the maximum dose. I think this was to allow for comparison across drugs because not all drugs were tested at the same dose range. You can undo the scaling by dividing by the maximum drug concentration.
If you are using the AUC data as a continuous variable, you don’t have to undo the scaling though. You can also find recalculated data online as well. I work at the Huang Lab at the University of Minnesota and we refitted the dose response curves and you can find that at our website.
You can find some more information at this post
