I am using the CTRP2 dataset and I’m interested to use AUC as a measure of drug sensitivity. For the analysis I want to run, the interpretation would be simplified if could inverse this value, that is, the area above the curve so that higher values would indicate higher drug sensitivity.
I’ve looked through the readme text file and understand how the AUC data was produced, however, I am not confident on how to generate the AAC value from the AUC value as I am not certain what the AUC is normalised too (if it is at all).
Is the total area 100, thus can I get AAC from 1 - AUC?
Alternatively, because of differences in drug concentrations tested, would it be better to normalise based on the maximum dose tested, and then invert AUC to AAC?