Issue with Drug sensitivity AUC (CTD^2)

Issues and Bugs
1

Hi,

I am encountering an issue while downloading the Drug Sensitivity AUC (CTD^2) file from the custom download section. Specifically, the values in the file do not appear to be AUC scores, as they fall outside the expected range of 0 to 1.

Could you please advise where I can access the matrix containing the actual AUC values?

Thank you,
Alessandro

2

Hi Alessandro - can you describe the unexpected values? Are they greater than 1, or negative? If they are greater than 1, that is possible if for example the compound is causing cell growth.

3

The value reported in the Drug Sensitivity AUC (CTD^2) file are positive values grater than 1. However this file should report Area Under the Curve (AUC) values which they typically range from 0 and 1. Correct AUC files are available for the SANGER and PRISM datasets (which I am currently using) but not for CTD. It does not look like the AUC matrix for the CTD dataset has been uploaded. Can you please help me with that?

Thanks!