Is it correct that only 22/78 SCLC cell lines have essentiality data?

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1

So far as I can determine there are 78 lines for small cell lung cancer indicated by the string SCLC in column 33 of Cell_lines_annotations_20181226.txt. It seems that only 22/78 of these lines have dependency data in CRISPRGeneDependency.csv
ACH-000698
ACH-000431
ACH-000871
ACH-000890
ACH-000355
ACH-000695
ACH-000187
ACH-000912
ACH-000921
ACH-000514
ACH-000257
ACH-000866
ACH-000559
ACH-000290
ACH-000639
ACH-000525
ACH-000767
ACH-000800
ACH-000790
ACH-000292
ACH-002051
ACH-001549
ACH-002077
Is there any known reason for this low proportion? In general, 75% (1095/1460) lines have dependency data, so it is surprising that SCLC has a much lower proportion.
Thanks for any clues.

2

Hello,

I don’t think there is a reason for the low proportion beyond our prioritization strategy. In general, we try to get coverage of as many disease contexts as possible rather than fully covering the CCLE set. At this time we’ve some coverage of SCLC which admittedly may only partially overlap with the CCLE set, and these days are adding other subtypes and models with in contexts for which we have no coverage.

Thanks,
Phil