Hi,
I’m new to DepMap and would like to ask how to interpret the p-value of enriched lineage. I read the previous threads and understand the p is calculated by using a t-test to compare the gene effects in selected cell lineages with all other lineages, so does it mean that if a gene has a small p-value, the gene is “specific” to this cell lineage?
Besides, I also noticed the genes with effects below -1 / -0.5 only partially match genes with small p-values in any lineage, so should we focus on genes both more “specific” (smaller p) and more dependent (larger negative gene effect) to a specific cell lineage?
Any guidance would be highly appreciated.
Thank you!
