I am wondering how the analysis is done for the “context” page, dependencies enriched in neuroblastoma (Neuroblastoma DepMap Context Summary). What does the t-value and p-value mean here? Does highly significance mean that there is a dependency for the gene/compound in most of the Neuroblastoma cell lines unrelated to other entities? Or does it mean that it is highly selective, so specific for neuroblastoma, and not a common essential gene? How can we extract all the “highly selective” genes in a certain disease?