How can I get synthetic lethal pairs from DepMap portal?

Q&A
1

I am in the process of collecting Synthetic Lethal Pairs. Where can i get SL pairs in DepMap portal.
Can i consider top 100 co-dependance genes as SL pairs for my query gene.

2

We don’t currently publish this information directly. You might derive estimates of this by analyzing the genomics data alongside the CRISPR data, for example by looking for associations between loss of function of gene X and dependency on gene Y.

3

Dear jmmcfari,

Many thanks for your reply.
Could you please help me more to understand which files should I consider (in downloads section) for loss of gene and dependancy for bulk of genes.
Waiting for your response. Thanks in advance.

Regards,
Sujit