Has Chronos2 been adopted in DepMap 25Q3 for gene-effect estimation?

Q&A
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1

Hi DepMap team,

I have a question regarding the model used for gene-effect estimation in the most recent releases.

I’m aware that Chronos was introduced starting in DepMap 21Q3.
Recently, a new version — Chronos2 — was published (https://www.biorxiv.org/content/10.1101/2025.04.24.650434v1).

Could you clarify:

1. Does the current DepMap release (25Q3) use Chronos2 to generate CRISPR gene-effect scores?

2. If yes, which DepMap release first adopted Chronos2?

3. If not, is there an approximate timeline for when Chronos2 will be incorporated into DepMap?

Thank you very much for your help!

2

Thank you to everyone who viewed this post. I reached out directly to the authors of Chronos and received a helpful reply, which I’m sharing here in case it helps others:

  • The current DepMap release does use Chronos2 for CRISPR gene-effect score estimation.

  • Chronos2 has been adopted since the 2023 Q4 (23Q4) release.

  • You can check the README file for each dataset to see whether gene effect scores were generated via Harmonia or an integrated Chronos2 run.

Thanks again, and I hope this update is useful to others with the same question!