I only found the original 2017 paper, but don’t know if there’s any update on it. Any description about those files and what do they imply? I read the readme file but still have a hard time understanding the file content, or how the data were generated and their proper usage.
Off the top of my head: there’s https://www.biorxiv.org/content/10.1101/720243v1.full which generally describes the analysis of CRISPR data. It is somewhat outdated as it refers to the previous method for estimating effects of gene knockout (CERES) which has since been replaced with Chronos but is generally is a good starting point. (Chronos is described in Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects | Genome Biology | Full Text)
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Thank you. and yes, it’s not updated. I might just have to read through all the depmap publications to get some idea of it.
