Gene effect on sensitivity to PARP inhibitors

Hi, I am trying to find out if some genes are related to sensitivity to PARP inhibitors in the context of breast cancer, so I have some doubts:

  • In a CRISPR vs Drug sensitivity plot, which parameter would be the best indicator of this sensitivity? would it be the correlation coefficient (pearson or spearman as appropriate)?
  • is there a more appropriate comparison that would fit better the purpose of my investigation?
    Thanks in advance.