CRISPR screens data for a drug effect

Q&A
1

Hi, I am interested in results of the CRISPR screens that identify genes that modulate the response (protect or sensitize) to osimertinib in a sensitive cell line. How can I find these data?

2

It sounds like you are interested in what I hear referred to as “anchor screens”. (ie: CRISPR screens in the presence of a drug which can be compared to response without the drug) However, none of the released DepMap data contain anchor screens.

The released DepMap CRISPR screens are all measuring the knockout of genes in the under that cell line’s growth conditions.

Thanks,
Phil

3

Hi Phil,
Thank you very much,
Michael