Hi DepMap team,
at first thank you for the great datasets and tools you are providing to the community.
I have recently observed a discrepancy between some mutation related files at depmap.org. E.g.:
- there are several cell lines, that have Y in CosmicHotspot of OmicsSomaticMutations.csv for NRAS gene, but they have 0 value in the indicator matrix Hotspot_Mutations.csv.
- These cell lines are
- also, it looks like Data Explorer of depmap.org shows only the mutations present in Hotspot_Mutations.csv, and not the ones in OmicsSomaticMutations.csv.
- also generally there are large discrepancies between OmicsSumoaticMutations (only CosmicHotspot mutations) and Hotspot_Mutations.csv for other genes also (based on some quick check)
Could you give some information regarding these these differences? Is it related to some processing from OmicsSumoaticMutations → Hotspot_Mutations? In this case, I assume one should use the (unprocessed) OmicsSumoaticMutations file and not Hotspot_Mutations / Data Explorer? Thank you,