Comparing custom drug profiling with PRISM

Hello,

I wanted to compare the sensitivity of some of my own cell lines (not available in DepMap) to a certain drug versus all other cell lines in PRISM. Of note, the drugs in question were used in the PRISM dataset.

Is that possible? If I use the same concentrations and timepoints used in PRISM is the comparison fair or the PRISM screening platform if so specific that such comparison would not be valid? Would you have suggestions on how to do it?

Thanks!

Joana