Comparing cell lines IC50 (trastuzumab)

Q&A
1

Hi
I am trying to compare all the breast cancer cell lines IC50 in response to Trastuzumab and to deruxtecan. The search works for cisplatin, but not for those drugs. The drugs are present in the database. Can anyone help me please? Thanks.

2

When I look up either of those drugs I get an info page for the drug that doesn’t list any datasets with data for that drug:

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This is what I’d expect to see if the drug database we use internally had an entry – but we have no experimental data for this drug. (Having a drug registered does not necessarily imply we’ll have data for it)

When you say the drugs are present in the database, are you saying that because it shows up when you search for it? Or do you know that there should be some experimental data in some dataset (which suggests that it failed to be loaded into the portal’s database)?

At this time, some drugs that we don’t have data for will have their annotations show up like this. (I think we’ll be moving to filter out compounds with no experimental data in the next release, so you won’t even see these compounds won’t even appear in search boxes in the future)

Thanks,
Phil

3

Thank you for your reply, Phil

So probably the drugs were not tested in cell lines.
I assumed that the description of the conpound would imply in cell line data.
As trastuzumab is “a classic”, “the first immunotherapy approved”, and still in use since the 1990s, it would have been tested (at least in breast cancer cell lines).
Thanks
Paula

4

Ah, Trastuzumab is an monoclonal antibody.

I suspect that is why it wasn’t included in the repurposing screens. I believe all of the PRISM Drug Repurposing project screens were limited to small molecule treatments. I don’t think the PRISM assay protocol could accommodate antibodies at the time the screen was performed.

Thanks,
Phil