Hi, very nice database. Two questions regarding defining strongly selective (most important question), and comparing expression to inhibition after knockdown.
Strongly selective can vary widely: some genes listed as such show no cell lines below -1 and some genes show the more interesting few lines below -1 (eg POU2F3).
— Is it possible to order genes simply: “number of lines below -1”
Also - most interesting is when a gene such as SOX2 (or POU2F3, SOX10) scores at -1 in a cell line (almost) only when it is expressed or highly expressed. So the biomarker of growth inhibition is simply expression of the gene. I know the size of the dot correlates with expression level but this perhaps could have more granularity?
Thank you again!!!