Regarding gene expression and gene effect score, I have found that the mRNA expression of some genes may be unrelated to or inversely proportional to the gene effect score. That is, the greater the dependence of the gene, the lower the gene expression. How can this be explained?
Hi SH_C,
A lower gene effect score can be interpreted as having a stronger viability effect. For example, if a gene has a gene effect score of -2 in Model A and 0 in Model B, this would indicate that Model A is more dependent on the gene than Model B.
An inverse correlation between expression and gene effect scores would indicate that a higher expression of a gene is correlated with a stronger dependency.
Thank you for the explanation. How should I interpret a significant positive correlation between gene effect score and mRNA expression, where lower gene effect scores (greater dependency) are associated with lower mRNA expression?
Yejie Yun <notifications@depmap.discoursemail.com>於 2026年8月4日週二，21:39寫道：
