Greetings, always thank you for your resource maintenance.
I have questions about the LoF information in the DepMap portal.
When I searched for cell lines with a TP53 mutation, I saw that the information on ACH-000012 is mismatched between its individual page and the result of the TP53 mutation page.
For example, TP53 was mutated and annotated with ‘Likely Loss-of-Function‘ in the ACH_000012 main page.
But in the TP53 mutation page, ACH-000012 is annotated with ‘FALSE’ in the ‘Likely LOF’ column.
Since I need to separate the groups by TP53-LoF mutation, this mismatch has confused me.
If I want to check the oncogenetic alterations information, which column should I check?
[Update]
I believe that the annotations of the V218del and H233del alterations appear to be inconsistent across different pages. This is because, as noted in my initial question, all cell lines carrying V218del are labeled as “Likely Loss-of-Function” on their individual pages, whereas in the summary page listing TP53 mutations, the same alteration is marked as FALSE under the “Likely LOF” column.
As in my previous inquiry, I would like to confirm which of these annotations should be considered correct.
