I noticed that for some genes, entries in the Annotation_Transcript column of CCLE_mutations file in the same cell line have changed for newer versions.
For example, the transcript of NFE2L2 gene for ACH-000488 cell line was ENST00000397062.3 in 20Q3, but in 20Q4, it is now ENST00000446151.2. As a result, the same amino acid change is annotated differently, e.g. for ACH-000488, p.D29G in 20Q3, but p.D13G in 20Q4.
What is the best way to interpret this change?