Hi,
In the file “Drug_sensitivity_AUC_(CTD^2)_subsetted”
Are the IC50 values informed in micromolar? If so, what do negative values mean?
Was the concentratation range (7.8-2000 nM) the same for all the calculated IC50 values?
Thank you very much in advance
From the file name, “Drug_sensitivity_AUC_(CTD^2)_subsetted” I’m guessing you generated this file from using the “Custom downloads” tool but also guessing from the name I see that it includes “AUC” so I suspect these values are not IC50s but AUC (area under the curve) values.
If you mean to ask “Was the concentratation range (7.8-2000 nM) the same for all the calculated AUC values?” then, I can answer that: No, I believe the dose range is different per compound.
If I recall correctly, when they performed the CTD^2 drug screens, they choose the dose ranges so that they would capture variation in activity across models. As a result, AUC is very useful for comparing models, but not as useful for comparing compounds.
Thanks,
Phil
