Some of the IC50 value in drug sensitivity databases is lower than 0. I am confused that how should we explain this data. For instance, IC50 of vinblastine (GDSC2:1004) on CCK81 is -5.550494585nM. (in Drug sensitivity IC50 (Sanger GDSC2)) Does it mean that this compound would enhance the cell proli…

Yeah,I think so.The Expression Public 22Q4 GDSC2 IC50 dataset shows that the maximum is about 6.9,which corresponds to ln(1000).Being an undergraduate student,I just couldn’t understand why it’s not clearly demonstrated,so confusing.

IC50 is lower than 0

Q&A

fschischlik October 6, 2022, 2:24pm 2

Hi Yuwei,

My bet is you are looking at ln(IC50). It’s always good practice to plot histograms of your values, this quickly explains such confusions.

Best,
Fio

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IC50 is lower than 0

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