Definitions of the 21Q2 mutations 'damaging', 'nonconserving', 'otherconserving' files

I was wondering if we could get a definition of how the boolean matrices were created? I’m assuming ‘bool_hotspot’ is 1 if the TCGA or COMSIC HotSpot column is true. However, for the ‘damaging’ file, how are you defining damaging? Protein Truncating Variants (PTVs), missense, in-frame indels? Same question for the nonconserving and otherconserving files.


Hi, you can find the definitions in this post.