Hello!

I have two questions regarding the late phases of Chronos algorithm.

- After estimating the fractional change in growth rate for gene
`g`

in cell line`c`

,

r_{c,g} = (R*_{c,g} / R_c) - 1

is there a scaling (such has forcing the median of known essential (resp. non-essential) genes to -1 (resp. 0)) or `r_{c,g}`

is the actual quantity found in `Achilles_gene_effect_Chronos.csv`

file?

- Are the probabilities in
`Achilles_gene_dependency_Chronos.csv`

computed as in CERES, that is the probability of the score being generated by the distribution of essential gene scores? If yes, it is done with BAGEL algorithm, or with a from-scratch EM, or with other?

Thanks for your work, and this forum!