I noticed a weird effect when looking at the various chronos datasets. In general, each independent dataset (Score OR Achilles Chronos vs Score+Achilles Chronos) seem pretty similar.
However, when you look at tumor suppressors that have a tendency to accelerate cell growth in the individual screens (TP53, NF1, PTEN), the increased growth rate looks like it has some weird artifact only in the combined Achilles/Score Chronos dataset, almost like it’s capped at a certain value.
For an obvious visual example :
I’ve read the Chronos paper a few times but am having trouble understanding why you would get this in the combined dataset. Is this something you guys have noticed before? Any ideas what’s going on here?