Cancer versus non-cancer dependencies

[Joshua_Dempster]

Generally, we look for the selectivity of a dependency within cancer cell lines, on the assumption that it’s not very likely for a gene to be a dependency in all cancers and only cancers. The gene’s page will indicate whether it appears to be selective. Forthcoming tools will provide more sophisticated ways of addressing this question with DepMap data. You can also check other sources like gnomAD to get some idea of the gene’s importance for human health.