arm-level CN status change, heterozygous or homozygous?

Q&A
1

Hi CCLE/DepMap team,

I’m interested in categorizing the status of a certain arm for all CCLE cell lines.

In the Cohen-Sharir_Table_S1.xlsx file, the Each chromosome arm is called as having copy gain (+1), loss (-1), or no change/no call (0). I would like to further ask if the loss is heterozygous or homozygous. Do you have any suggestions? What’s the formula to calculate from the segment data for a certain arm? Thanks a lot!

Best,
Anlu

2

Hello,

This data came from the publication Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition. That should cover the methodology for how this was derived.

Thanks,
Phil