DepMap releases data bi-annually to the DepMap Portal, along with new tools and other resources for you to explore. Read more about each release below.
24Q4
Highlights
- 35 new CRISPR screens including adult and pediatric models
- New WGS effort for all DepMap models with CRISPR screens
- Re-processing of Humagne screens, change to SequenceMaxCorr metric and updates to pDNA batch metadata
- New Resources page
- Change to standardize and consolidate file names and dataset versions on the Downloads page
Read the full release notes here.
24Q2
Highlights
- Data Explorer 2.0
- Centralized Data Hub in the portal
- New genomic features: PureCN absolute copy number data and Omics Signatures
- This PRISM Repurposing dataset now contains two screens
- New “pDNA” reference for Humagne screens
- Refinment of sequence correlation QC metric
- Omics pipeline updates
- RNA-strandness correction
Read the full release notes here.
23Q4
Highlights
- New CRISPR Cas12 dual-guide Humage library
- Updates to mutation pipeline for better germline filtering and more comprehensive rescuing of cancer-related variants.
- Legacy Copy Number from SNParray dropped
- New profile-level expression (TPM) files
- Removal of Confounding Components (RCPC) for Screen Quality Correction
- Celligner app update
Read the full release notes here.
23Q2
Highlights
- New metadata columns
- Standardized media annotations
- New Target Discovery app
- OmicsSomaticMutationsMAFProfile.maf now available
Read the full release notes here.
22Q4
Highlights
- New Oncotree annotations for cell lines
- Updated data structure including introduction of Model Conditions
- Gene set enrichment included as part of release files
- Omics pipeline updates
- CRISPR data produced by joint Chronos run on all included Screens for a Model in different conditions
- New CRISPR NaiveScreenEffect file
- Release of binary mutation matrices for locations in the guide libraries (KY, Avana and Humagne) used for Achilles’ ancestry bias correction
- Updates to Achilles QC to include: SequenceMeanReadsPerGuide,
- SequenceNNMD/ScreenNNMD, and SequenceMaxCorr
- Removal of legacy SNP-based copy number calling and hybrid capture/raindance-based mutation calling
Read the full release notes here.
