I find a lot of the CRISPR co-depency top hits that I’ve been looking at for a while have changed in the new update(?). The top gene CRISPR co-dependencies are now often changed and I find that the new genes are from a set of 45 screens (newly added) - perhaps genes that have been left out of libraries before. However, the co-dependencies makes little sense to me, compared to the ones derived from >1000 datasets and so far only gives me more ‘noise’. Is it possible to retrieve gene specific co-dependency data from earlier version to exclude these newly added 45 screens or otherwise work around this?
Best,
Peter
