I find a lot of the CRISPR co-depency top hits that I’ve been looking at for a while have changed in the new update(?). The top gene CRISPR co-dependencies are now often changed and I find that the new genes are from a set of 45 screens (newly added) - perhaps genes that have been left out of libraries before. However, the co-dependencies makes little sense to me, compared to the ones derived from >1000 datasets and so far only gives me more ‘noise’. Is it possible to retrieve gene specific co-dependency data from earlier version to exclude these newly added 45 screens or otherwise work around this?
I’ve found the same thing as well. The gene co-dependencies up until 25Q3 made sense for known co-functions and suggested plausible hypotheses for previously undocumented links between genes that correlated with orthogonal data. Now many of the co-dependencies, even many of the top few, seem completely random.
I know that 2024Q4 was good for me. In of of the following updates there was added 45 screens with genes not previously screened before. Somehow these genes very very often come up as the most co-dependent but make little sense.
