# \#compound-screens **URL:** https://forum.depmap.org/tag/compound-screens/2.md [Latest](https://forum.depmap.org/latest.md) · [Categories](https://forum.depmap.org/categories.md) · [Tags](https://forum.depmap.org/tags.md) --- ## [Prism secondary drug screening unable to download (google cloud access denied)](https://forum.depmap.org/t/prism-secondary-drug-screening-unable-to-download-google-cloud-access-denied/4027)
**Author:** [@Dylan\_Wang](https://forum.depmap.org/u/Dylan_Wang)\ **Replies:** 3\ **Last updated:** [December 21, 2025, 1:46pm UTC](https://forum.depmap.org/t/prism-secondary-drug-screening-unable-to-download-google-cloud-access-denied/4027 "2025-12-21T13:46:44Z")
Hi DepMap team, Looks like we are all unable to download the PRISM secondary drug screening results. My error message is “google cloud access denied”. Could you please help solve this issue? Thank you so very much. --- ## [Comparing custom drug profiling with PRISM](https://forum.depmap.org/t/comparing-custom-drug-profiling-with-prism/4502)
**Author:** [@joanaM](https://forum.depmap.org/u/joanaM)\ **Replies:** 0\ **Last updated:** [November 3, 2025, 2:40pm UTC](https://forum.depmap.org/t/comparing-custom-drug-profiling-with-prism/4502 "2025-11-03T14:40:13Z")
Hello, I wanted to compare the sensitivity of some of my own cell lines (not available in DepMap) to a certain drug versus all other cell lines in PRISM. Of note, the drugs in question were used in the PRISM dataset. I… --- ## [Request about treatment metadata for "PRISM Repurposing Public 24Q2" release](https://forum.depmap.org/t/request-about-treatment-metadata-for-prism-repurposing-public-24q2-release/4474)
**Author:** [@Abofazl\_Arab](https://forum.depmap.org/u/Abofazl_Arab)\ **Replies:** 1\ **Last updated:** [September 26, 2025, 1:57pm UTC](https://forum.depmap.org/t/request-about-treatment-metadata-for-prism-repurposing-public-24q2-release/4474 "2025-09-26T13:57:21Z")
Hi DepMap team, In the “PRISM Repurposing Public 24Q2” data I downloaded from DepMap portal, treatment IDs (e.g., BRD-K000#####-###-##-#) are not fully matched with this table. However, this could be a great resource pr… --- ## [Drug-Target validation using CRISPR and PRISM repurposing dataset](https://forum.depmap.org/t/drug-target-validation-using-crispr-and-prism-repurposing-dataset/4268)
**Author:** [@Mohamed\_El\_Moussaoui](https://forum.depmap.org/u/Mohamed_El_Moussaoui)\ **Replies:** 6\ **Last updated:** [July 1, 2025, 9:01am UTC](https://forum.depmap.org/t/drug-target-validation-using-crispr-and-prism-repurposing-dataset/4268 "2025-07-01T09:01:01Z")
Hello, i am working on validating Drug-target screens to validate the hypothesis that the drug is inhibiting the gene product by examining that the gene ko and the drug have similar signatures (effects). however, i am lo… --- ## [Question about the naming rule for drugs in Custom Downloads data](https://forum.depmap.org/t/question-about-the-naming-rule-for-drugs-in-custom-downloads-data/4299)
**Author:** [@WYB](https://forum.depmap.org/u/WYB)\ **Replies:** 1\ **Last updated:** [June 26, 2025, 1:29pm UTC](https://forum.depmap.org/t/question-about-the-naming-rule-for-drugs-in-custom-downloads-data/4299 "2025-06-26T13:29:26Z")
Greeting, We have a certain question about the naming rule for drugs in Custom Downloads data. Since there are data from different sources and your team has formated them into fixed formats, we wonder if the names of dr… --- ## [Question about PRISM Drug sensitivity AUC data](https://forum.depmap.org/t/question-about-prism-drug-sensitivity-auc-data/78)
**Author:** [@Jiang\_shaowen](https://forum.depmap.org/u/Jiang_shaowen)\ **Replies:** 7\ **Last updated:** [April 8, 2025, 8:30am UTC](https://forum.depmap.org/t/question-about-prism-drug-sensitivity-auc-data/78 "2025-04-08T08:30:16Z")
Dear DepMap developers, Thanks for developing this amazing tool! I have some questions regarding the data structure, especially for the PRISM drug AUC data. I noticed that some drugs have multiple BROAD IDs, I guess … --- ## [Availability of RNA-seq data after drug treatment](https://forum.depmap.org/t/availability-of-rna-seq-data-after-drug-treatment/4099)
**Author:** [@Giacomo\_Graziano](https://forum.depmap.org/u/Giacomo_Graziano)\ **Replies:** 1\ **Last updated:** [April 1, 2025, 6:22pm UTC](https://forum.depmap.org/t/availability-of-rna-seq-data-after-drug-treatment/4099 "2025-04-01T18:22:30Z")
Hello, I am looking for RNA-seq data of cancer cell lines treated with specific drugs. Could you please provide information on where I can find these datasets within DepMap or if they are available for download? Thank y… --- ## [Mocs3 interacting drugs](https://forum.depmap.org/t/mocs3-interacting-drugs/4012)
**Author:** [@MikeSusaeta](https://forum.depmap.org/u/MikeSusaeta)\ **Replies:** 0\ **Last updated:** [February 26, 2025, 9:14am UTC](https://forum.depmap.org/t/mocs3-interacting-drugs/4012 "2025-02-26T09:14:08Z")
Hello, I am a 3rd year PhD student looking to understand how can I look for the CRISPR libraries and select an existing compound that could inhibit my gene of interest MOCS3. If you could help me out with this, I would v… --- ## [Compound instance](https://forum.depmap.org/t/compound-instance/3570)
**Author:** [@princy](https://forum.depmap.org/u/princy)\ **Replies:** 0\ **Last updated:** [September 11, 2024, 12:28pm UTC](https://forum.depmap.org/t/compound-instance/3570 "2024-09-11T12:28:47Z")
What is the difference between ELOXATIN(BRD:BRD-K78960041-001-03-2) and ELOXATIN(BRD:BRD-K78960041-001-05-7) for Primary PRISM screen. The log 2 fold change values for them are pretty different even though the compound i… --- ## [LMFI(log2 median fluorescence intensity values)](https://forum.depmap.org/t/lmfi-log2-median-fluorescence-intensity-values/3448)
**Author:** [@damu](https://forum.depmap.org/u/damu)\ **Replies:** 0\ **Last updated:** [July 21, 2024, 1:13pm UTC](https://forum.depmap.org/t/lmfi-log2-median-fluorescence-intensity-values/3448 "2024-07-21T13:13:51Z")
What is the meaning of LMFI from PRISM Repurposing Public 24Q2? Does a lower LMFI score of drug-treated group mean more sensitive than a higher LMFI score of control-group? --- ## [PRISM Batch effect](https://forum.depmap.org/t/prism-batch-effect/3439)
**Author:** [@bav](https://forum.depmap.org/u/bav)\ **Replies:** 0\ **Last updated:** [July 19, 2024, 12:43pm UTC](https://forum.depmap.org/t/prism-batch-effect/3439 "2024-07-19T12:43:46Z")
Hi DepMap! I noticed what appears to be a batch effect, and wanted to share - Plotted below are the median PRISM LFCs (primary screen), across all compounds, sorted on DepMap\_ID (accessed from the Custom Downloads inter… --- ## [User drug sensitivity (PRISM Repurposing Primary screen)](https://forum.depmap.org/t/user-drug-sensitivity-prism-repurposing-primary-screen/3176)
**Author:** [@Evan\_King](https://forum.depmap.org/u/Evan_King)\ **Replies:** 3\ **Last updated:** [April 24, 2024, 1:41pm UTC](https://forum.depmap.org/t/user-drug-sensitivity-prism-repurposing-primary-screen/3176 "2024-04-24T13:41:14Z")
Hello, What do the values in this mean? Log2 ic50? --- ## [9-ING-41 repurposing hub data](https://forum.depmap.org/t/9-ing-41-repurposing-hub-data/3108)
**Author:** [@jcoats](https://forum.depmap.org/u/jcoats)\ **Replies:** 1\ **Last updated:** [April 5, 2024, 3:10pm UTC](https://forum.depmap.org/t/9-ing-41-repurposing-hub-data/3108 "2024-04-05T15:10:31Z")
Hi, Link: 9-ING-41 DepMap Compound Summary 9-ING-41 appears to have been screened but the data from the repurposing hub doesn’t load. Is this data available? Thanks. --- ## [How to find a specific analysis](https://forum.depmap.org/t/how-to-find-a-specific-analysis/3127)
**Author:** [@MikeSusaeta](https://forum.depmap.org/u/MikeSusaeta)\ **Replies:** 1\ **Last updated:** [March 12, 2024, 1:09pm UTC](https://forum.depmap.org/t/how-to-find-a-specific-analysis/3127 "2024-03-12T13:09:04Z")
I want to find information on RESISTANT breast cancer cells against two specific compounds. Have been playing with the program a bit and I really do not get how to filter for cells that show a resistance to a certain che… --- ## [Data issue with PRISM drug repurposing dataset](https://forum.depmap.org/t/data-issue-with-prism-drug-repurposing-dataset/3124)
**Author:** [@Karen\_Wong](https://forum.depmap.org/u/Karen_Wong)\ **Replies:** 2\ **Last updated:** [March 8, 2024, 5:25pm UTC](https://forum.depmap.org/t/data-issue-with-prism-drug-repurposing-dataset/3124 "2024-03-08T17:25:11Z")
Hi, I’ve been analyzing compound screening data from the PRISM Repurposing Secondary Screen and have encountered a potential data or technical artifact. For example, with the compound SN38, I noticed that nearly all cel… --- ## [Interpretation of Drug sensitivity AUC and Logfold change value](https://forum.depmap.org/t/interpretation-of-drug-sensitivity-auc-and-logfold-change-value/492)
**Author:** [@xmc](https://forum.depmap.org/u/xmc)\ **Replies:** 8\ **Last updated:** [March 8, 2024, 2:07pm UTC](https://forum.depmap.org/t/interpretation-of-drug-sensitivity-auc-and-logfold-change-value/492 "2024-03-08T14:07:41Z")
Dear Depmap team, I have some questions regarding how to interpret Drug sensitivity AUC and Logfold change value during compound screening on cell lines: If cell line A has the higher the drug sensitivity AUC than cel… --- ## [Data Removed? Navitoclax single agent data](https://forum.depmap.org/t/data-removed-navitoclax-single-agent-data/2952)
**Author:** [@nschomer](https://forum.depmap.org/u/nschomer)\ **Replies:** 5\ **Last updated:** [February 12, 2024, 3:31pm UTC](https://forum.depmap.org/t/data-removed-navitoclax-single-agent-data/2952 "2024-02-12T15:31:23Z")
As of yesterday, there were several data sets for Navitoclax as a single agent (both Sanger data sets, IC50 and AUC), but today the option to choose navitoclax as a single agent is not available anymore (08Dec2023). Has… --- ## [Prism drug repurposing score ](https://forum.depmap.org/t/prism-drug-repurposing-score/2800)
**Author:** [@Malini\_Rajan](https://forum.depmap.org/u/Malini_Rajan)\ **Replies:** 1\ **Last updated:** [September 12, 2023, 12:50pm UTC](https://forum.depmap.org/t/prism-drug-repurposing-score/2800 "2023-09-12T12:50:04Z")
What does prism drug repurposing score of -0.5 mean ? Is it the cell the line is strongly sensitive or weekly sensitive to the drug ? --- ## [Viability at a given dosage from AUC](https://forum.depmap.org/t/viability-at-a-given-dosage-from-auc/384)
**Author:** [@sanjusinha7](https://forum.depmap.org/u/sanjusinha7)\ **Replies:** 2\ **Last updated:** [August 17, 2023, 5:33pm UTC](https://forum.depmap.org/t/viability-at-a-given-dosage-from-auc/384 "2023-08-17T17:33:06Z")
For PRISM 19Q4, secondary screen, I am wondering if we can compute % killing at a required dosage from AUC values. For each drug-cell line pair, we have available fitted curve upper/lower limits & slope. If I am not mis… --- ## [Difference between Mifepristone Compounds](https://forum.depmap.org/t/difference-between-mifepristone-compounds/2726)
**Author:** [@DanielG](https://forum.depmap.org/u/DanielG)\ **Replies:** 0\ **Last updated:** [July 28, 2023, 3:58pm UTC](https://forum.depmap.org/t/difference-between-mifepristone-compounds/2726 "2023-07-28T15:58:24Z")
Hi, My group and I performed a primary drug screen two-class comparison to investigate how a particular mutation in our cancer type predicts for drug sensitivity or resistance based on a particular drug’s mechanism of a… --- ## [How to inverse the AUC value for drug sensitivity screens](https://forum.depmap.org/t/how-to-inverse-the-auc-value-for-drug-sensitivity-screens/2175)
**Author:** [@LJMH](https://forum.depmap.org/u/LJMH)\ **Replies:** 0\ **Last updated:** [January 5, 2023, 2:31pm UTC](https://forum.depmap.org/t/how-to-inverse-the-auc-value-for-drug-sensitivity-screens/2175 "2023-01-05T14:31:20Z")
I am using the CTRP2 dataset and I’m interested to use AUC as a measure of drug sensitivity. For the analysis I want to run, the interpretation would be simplified if could inverse this value, that is, the area above the… --- ## [About compounds](https://forum.depmap.org/t/about-compounds/1993)
**Author:** [@dr.uchida](https://forum.depmap.org/u/dr.uchida)\ **Replies:** 0\ **Last updated:** [October 31, 2022, 1:47pm UTC](https://forum.depmap.org/t/about-compounds/1993 "2022-10-31T13:47:01Z")
Are Her2 inhibitors such as trastuzumab and pertuzumab not registered in the compounds? --- ## [PRISM data and identified cell lines](https://forum.depmap.org/t/prism-data-and-identified-cell-lines/1863)
**Author:** [@turonvincent](https://forum.depmap.org/u/turonvincent)\ **Replies:** 0\ **Last updated:** [September 20, 2022, 4:30pm UTC](https://forum.depmap.org/t/prism-data-and-identified-cell-lines/1863 "2022-09-20T16:30:22Z")
Dear DepMap forum, I did a PRISM screen to compare the sensitivity towards to different versions of a compound. I then calculated a sensitivity ratio based on the IC50 in the data. I now have a list of cell lines, and I… --- ## [Antibody Drug Conjugates](https://forum.depmap.org/t/antibody-drug-conjugates/1748)
**Author:** [@sd\_r](https://forum.depmap.org/u/sd_r)\ **Replies:** 0\ **Last updated:** [August 29, 2022, 4:10pm UTC](https://forum.depmap.org/t/antibody-drug-conjugates/1748 "2022-08-29T16:10:14Z")
Hello, Are there any compound screen data for antibody drug conjugates (ADC), specifically for Herceptin, TDM1 or trastuzumab deruxtecan? If so, please let me know which files to look at. Thank you --- ## [Drug sensitivity (PRISM Repurposing Primary Screen) 19Q4](https://forum.depmap.org/t/drug-sensitivity-prism-repurposing-primary-screen-19q4/314)
**Author:** [@Mirella-Evotec](https://forum.depmap.org/u/Mirella-Evotec)\ **Replies:** 2\ **Last updated:** [July 18, 2022, 12:12pm UTC](https://forum.depmap.org/t/drug-sensitivity-prism-repurposing-primary-screen-19q4/314 "2022-07-18T12:12:02Z")
Hi I’m trying to select a list of cell lines with different drug sensitivity to Olaparib using Drug sensitivity (PRISM Repurposing Primary Screen) 19Q4. How do we interpret the log2 fold change numbers: \< 0 is sensitive… --- ## [NA targets in the PRISM 19Q4 dataset](https://forum.depmap.org/t/na-targets-in-the-prism-19q4-dataset/1207)
**Author:** [@SongSong](https://forum.depmap.org/u/SongSong)\ **Replies:** 2\ **Last updated:** [May 24, 2022, 2:12am UTC](https://forum.depmap.org/t/na-targets-in-the-prism-19q4-dataset/1207 "2022-05-24T02:12:30Z")
Dear DepMap forum, Hi, I have questions about the PRISM 19Q4 dataset. While I checked the secondary-screen-replicate-treatment-info.csv file, some drugs are not targeting the genes. (i.e., NA value in target column) I… --- ## [Are IC50 values downloadable from DepMap log or z-transformed or normalized in some way?](https://forum.depmap.org/t/are-ic50-values-downloadable-from-depmap-log-or-z-transformed-or-normalized-in-some-way/1143)
**Author:** [@Ashutosh\_Pandey](https://forum.depmap.org/u/Ashutosh_Pandey)\ **Replies:** 1\ **Last updated:** [May 3, 2022, 3:01pm UTC](https://forum.depmap.org/t/are-ic50-values-downloadable-from-depmap-log-or-z-transformed-or-normalized-in-some-way/1143 "2022-05-03T15:01:56Z")
Hello, I would like to know if IC50 values that can be downloaded as part of the files below are transformed (such as log transformation, z-scores). I couldn’t find any README file that explains how those values were de… --- ## [Availability of cell lines from DepMap](https://forum.depmap.org/t/availability-of-cell-lines-from-depmap/1301)
**Author:** [@spm6456](https://forum.depmap.org/u/spm6456)\ **Replies:** 3\ **Last updated:** [April 12, 2022, 6:34am UTC](https://forum.depmap.org/t/availability-of-cell-lines-from-depmap/1301 "2022-04-12T06:34:44Z")
Hi, I am wondering if researchers can avail a set of cell lines for their research upon request? The intent is to screen few selected small molecules. Alternatively, are there any resources/services to get this done? I a… --- ## [Is it possible to separate drug sensitivity into two categories: Sensitive / Resistance?](https://forum.depmap.org/t/is-it-possible-to-separate-drug-sensitivity-into-two-categories-sensitive-resistance/1262)
**Author:** [@dowlddh](https://forum.depmap.org/u/dowlddh)\ **Replies:** 1\ **Last updated:** [April 7, 2022, 3:46pm UTC](https://forum.depmap.org/t/is-it-possible-to-separate-drug-sensitivity-into-two-categories-sensitive-resistance/1262 "2022-04-07T15:46:21Z")
Dear Depmap, Hello, I have some questions. Is it possible to separate drug sensitivity into two categories: Sensitive / Resistance? If I use AUC to distinguish, should I set the threshold for all drugs differently? Is… --- ## [EGFR inhibitor data of lung cancer cells](https://forum.depmap.org/t/egfr-inhibitor-data-of-lung-cancer-cells/990)
**Author:** [@jasonlai](https://forum.depmap.org/u/jasonlai)\ **Replies:** 1\ **Last updated:** [January 26, 2022, 9:17pm UTC](https://forum.depmap.org/t/egfr-inhibitor-data-of-lung-cancer-cells/990 "2022-01-26T21:17:25Z")
Dear DepMap team, I am analyzing the responses of lung cancer cells to EGFR small molecules. Specifically, many of these lung cancer cells appear to have AUC values close to 1 (for example, Gefitinib which was designed… [Next page](https://forum.depmap.org/tag/compound-screens/2.md?match_all_tags=true&page=1&tags%5B%5D=compound-screens)