# Is it possible to separate drug sensitivity into two categories: Sensitive / Resistance?

**URL:** <https://forum.depmap.org/t/is-it-possible-to-separate-drug-sensitivity-into-two-categories-sensitive-resistance/1262>\
**Category:** Q&A\
**Tags:** compound-screens\
**Created:** [March 15, 2022, 12:57pm UTC](https://forum.depmap.org/t/is-it-possible-to-separate-drug-sensitivity-into-two-categories-sensitive-resistance/1262 "2022-03-15T12:57:14Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![dowlddh](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/dowlddh/32/442_2.png) [@dowlddh](https://forum.depmap.org/u/dowlddh)\
**Post date:** [March 15, 2022, 12:57pm UTC](https://forum.depmap.org/t/is-it-possible-to-separate-drug-sensitivity-into-two-categories-sensitive-resistance/1262/1 "2022-03-15T12:57:14Z")

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Dear Depmap,

Hello, I have some questions. Is it possible to separate drug sensitivity into two categories: Sensitive / Resistance?

If I use AUC to distinguish, should I set the threshold for all drugs differently?

Is there a good way?

Best,  
Jay Lee

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**Author:** ![aboghossian](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/aboghossian/32/73_2.png) [@aboghossian](https://forum.depmap.org/u/aboghossian)\
**Post date:** [April 7, 2022, 3:46pm UTC](https://forum.depmap.org/t/is-it-possible-to-separate-drug-sensitivity-into-two-categories-sensitive-resistance/1262/2 "2022-04-07T15:46:21Z")

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Hi Jay,

To binarize drug sensitivity we usually use a viability threshold of 30% which corresponds to a log-fold change of log2(0.3) or about -1.73. For AUC it is a little bit trickier but an AUC of less than about 0.8 is a good starting point for a threshold.

Hope that helps!

Andrew Boghossian