# How to interpret the results about “Aneuploidy score”, "Ploidy" and " Genome.doublings"

**URL:** <https://forum.depmap.org/t/how-to-interpret-the-results-about-aneuploidy-score-ploidy-and-genome-doublings/2676>\
**Category:** Q&A\
**Created:** [July 5, 2023, 5:02pm UTC](https://forum.depmap.org/t/how-to-interpret-the-results-about-aneuploidy-score-ploidy-and-genome-doublings/2676 "2023-07-05T17:02:14Z")\
**Posts on this page:** 4\
**Page:** 1

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**Author:** ![Marjan\_Shirzai](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/marjan_shirzai/32/888_2.png) [@Marjan\_Shirzai](https://forum.depmap.org/u/Marjan_Shirzai)\
**Post date:** [July 5, 2023, 5:02pm UTC](https://forum.depmap.org/t/how-to-interpret-the-results-about-aneuploidy-score-ploidy-and-genome-doublings/2676/1 "2023-07-05T17:02:14Z")

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using [DepMap Data Downloads](https://depmap.org/portal/download/custom/) I created a data set that contains information about cell lines and drug sensitivity. The second to fourth row contains aneuploidy score, ploidy and genome doublings information. How are these scores calculated and how can I interpret the information?

 ![dataFrame1](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/1X/2fcb0bf06e6985afa85b62845efd61df10bf2c68.png)  
 ![dataFrame2](https://canada1.discourse-cdn.com/flex035/uploads/depmap/original/1X/08a5f4377ac4f7b560b53189774d8f6e6ca27b36.png)

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**Author:** ![simz](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/simz/32/440_2.png) [@simz](https://forum.depmap.org/u/simz)\
**Post date:** [July 5, 2023, 9:31pm UTC](https://forum.depmap.org/t/how-to-interpret-the-results-about-aneuploidy-score-ploidy-and-genome-doublings/2676/2 "2023-07-05T21:31:34Z")

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Hi,

These scores came from [this paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8262644/). I’d recommend referring to their method section for details on how these scores are calculated.

Thanks,  
Simone

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**Author:** ![Marjan\_Shirzai](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/marjan_shirzai/32/888_2.png) [@Marjan\_Shirzai](https://forum.depmap.org/u/Marjan_Shirzai)\
**Post date:** [July 12, 2023, 1:03pm UTC](https://forum.depmap.org/t/how-to-interpret-the-results-about-aneuploidy-score-ploidy-and-genome-doublings/2676/3 "2023-07-12T13:03:01Z")

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Thank you for the answer Simone.

Unfortunately I can’t find anything about the ploidy values shown in the table. What do they mean and how are they determined?

Thank you,  
Marjan

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**Author:** ![simz](https://yyz1.discourse-cdn.com/flex035/user_avatar/forum.depmap.org/simz/32/440_2.png) [@simz](https://forum.depmap.org/u/simz)\
**Post date:** [July 12, 2023, 6:35pm UTC](https://forum.depmap.org/t/how-to-interpret-the-results-about-aneuploidy-score-ploidy-and-genome-doublings/2676/4 "2023-07-12T18:35:10Z")

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Hi Marjan,

The team members that were involved in data computation have left so I am not 100% certain, but my guess would be that this ploidy was one of the outputs from the ABSOLUTE algorithm and was taken from the CCLE2 paper.

Best,  
Simone